Original papers


Uemura, S., Mochizuki, M., Kato, Y., Mioka, T., Watanabe, R., Fuchita, M., Yamada, M., Noda, Y., Moriguchi, T. and Abe, F. (2024) Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. J. Biochem. in press.


Mochizuki,T., Tanigawa, T., Shindo, S., Suematsu, M., Oguchi, Y., Mioka, T., Kato, Y., Fujiyama, M., Hatano, E., Yamaguchi, M., Chibana, H., and Abe, F. Activation of CWI pathway through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae. Mol. Biol. Cell34, ar92.


Ishii, R.Fukui, A.Sakihama, Y.Kitsukawa, S.Futami, A.Mochizuki, T., Nagano, M., Toshima, J., and Abe, F. (2022) Substrate-induced differential degradation and partitioning of the two tryptophan permeases Tat1 and Tat2 into eisosomes in Saccharomyces cerevisiae. Biochim. Biophys. Acta Biomembr1864, 183858.

Funada, C.,Tanino, N., Fukaya, M,, Mikajiri, Y., Nishiguchi, M., Otake, M.,, Nakasuji, H., Kawahito, R., and Abe, F. (2022) SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae. Biochim. BiophysActa Gen. Subj. 1866, 130049.



Heidelman, M., Dhakal, B., Gikunda, M., Silva, K. P. T., Risal, L., Rodriguez, A. I., Abe, F., and Urayama, P. (2021) Cellular NADH and NADPH conformation as a real-time fluorescence-based metabolic indicator under pressurized conditions. Molecules 26, 5020.



Uemura, S., Mochizuki, T., Amemiya, K., Kurosaka, G., Yazawa, M., Nakamoto, K., Ishikawa, Y., Izawa, S., and Abe, F. (2020) Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure. J. Cell Sci.133, ics24555, selected for "Research Highlights".

Dobriyala, N., Sagarikaa, P., Shrivastavaa, A., Vermaa, A.K., Islama, Z., Guptaa, P. , Mochizuki, T., Abe, F., Sahi, C. (2020) Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae stabilizes amino acid permeases. Biochim. Biophys. Acta 1862, 183435.



Kurosaka, G., Uemura, S., Mochizuki, T., Kozaki, Y., Hozumi, A., Suwa, S., Ishii, R., Kato, Y., Imura, S., Ishida, N., Noda, Y., and Abe, F. (2019) A novel ER membrane protein Ehg1/May24 plays a critical role in maintaining multiple nutrient permeases in yeast under high-pressure perturbation. Sci. Rep9, 18341.

Amano, K., Ishii, R., Mochizuki, T., Takatsu, S., and Abe, F. (2019) Hyperactive mutation occurs adjacent to the essential glutamate 286 for transport in the yeast tryptophan permease Tat2. Biochem. Biphys. Res. Commun.509, 1047-1052.

Ishii, R. , Aramaki, M.Mochizuki, T., and Abe, F. (2019) Identification of a regulatory element for yeast tryptophan permease Tat2 ubiquitination using high hydrostatic pressure. High Pressure Res. 39, 258-266.



Nemoto, S., Ohnuki, S., Abe, F., and Ohya Y. (2018) Simulated microgravity triggers characteristic morphology and stress response in Saccharomyces cerevisiae. Yeast doi: 10.1002/yea.3361

Kurosaka, G. and Abe, F. (2018) The YPR153W gene is essential for the pressure tolerance of tryptophan permease Tat2 in the yeast Saccharomyces cerevisiae. High Pressure Res. 38, 90-98.



Uemura, S., Mochizuki, T., Hashimoto, T., Masukawa, M., Kurosaka, G., and Abe, F. (2017) Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1859, 2076-2085

Kitamura, K., Kinsui, E. Z., and Abe, F. (2017)Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim. Biophys. Acta 1864, 393-398.



Nagano, Y., Konishi, M., Nagahama, T., Kubota, T., Abe, F., and Hatada, Y. (2016) Retrieval of deeply buried culturable fungi in marine subsurface sediments, Suruga-Bay, Japan. Fungal Ecol. 20, 256-259.



Mochizuki, T., Kimata, Y., Uemura, S. and Abe, F. (2015) Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae. FEMS Yeast Res 15, fov044.

Sawada, K., Sato, T., Hamajima, H., Jayakody, L.N., Hirata, M., Yamashiro, M., Tajima, M., Mitsutake, S., Nagao, K., Tsuge, K., Abe, F., Hanada and K., Kitagaki, H. (2015) Appl. Environ. Microbiol. 81, 3688-3698



Kawai, K., Moriya, A., Uemura, S. and Abe, F. (2014) Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae. Eukaryotic Cell 13, 1380-1392.

Klippel, B., Sahm, K., Basner, A., Wiebusch, S., John, P., Lorenz, U., Peters, A., Abe, F., Takahashi, K., Kaiser, O., Goesmann, A., Jaenicke, S., Grote, R., Horikoshi, K., Antranikian, G. (2014) Carbohydrate-active enzymes identified by metagenomic analysis of deep-sea sediment bacteria. Extremophiles.18, 853-863.

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. and Inokuchi, J. (2014) The loss of hydroxyl groups from the ceramide moiety leads to a reduction in the lateral diffusion of membrane proteins in Saccharomyces cerevisiae. J. Lipid Res. 55, 1343-1356.

Usami, Y., Uemura, S., Mochizuki, T., Morita, A., Shishido, F., Inokuchi, J. and Abe, F. (2014) Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2. Biochim. Biophys. Acta1838, 1719-1729.



Uemura, S. , Go, S., Shishido, F., Inokuchi, J. (2013) Expression machinery of GM4: The excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GN4 synthesis in mammalian cells. Glycoconj. J. 31, 101-108.

Watanabe T. M., Imada, K., Yoshizawa, K., Nishiyama, M., Kato, C., Abe, F., Morikawa, T. J., Kinoshita, M., Fujita, H. and Yanagida, T. (2013) Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure. PLoS One 8: e73212.

Kanda, N. and Abe, F. (2013) Structural and functional implications of the yeast high-affinity tryptophan permease Tat2. Biochemistry 52, 4296-4307.

Suzuki, A., Mochizuki, T., Uemura, S., Hiraki, T. and Abe, F. (2013) Pressure-induced endocytic degradation of the yeast low-affinity tryptophan permease Tat1 is mediated by Rsp5 ubiquitin ligase and functionally redundant PPxY-motif proteins. Eukaryotic Cell 12, 990-997.

Abe, F. and Usui, K. (2013) Effects of high hydrostatic pressure on the dynamic structure of living Escherichia coli membrane: a study using high-pressure time-resolved fluorescence anisotropy measurement. High Pressure Research 33, 278-284.

Kitagawa, S., Sugiyama, M., Motoyama, M., and Abe, F. (2013) Soy peptides enhance yeast cell growth at low temperature. Biotechnol. Lett. 35, 375-382.

Takahashi-Ando, N., Tanaka, A., Sekimoto, Y., Yamaguchi, K., Echigo, A., Usami R., Abe, F., and Minegishi, H. (2013) Functional screening for resistance genes against trichothecenes in the library of Saccharomyces cerevisiae deletion mutants. Mycotoxins 63, 9-15.



Usui, K., Hiraki, T., Kawamoto, J., Kurihara, T., Nogi, Y., Kato, C., and Abe, F. (2012) Eicosapentaenoic acid plays a role in stabilizing dynamic membrane structure in the deep-sea piezophile Shewanella violacea: a study employing high-pressure time-resolved fluorescence anisotropy measurement. Biochim. Biophys. Act1818, 574-583.

Hiraki, T., Sekiguchi, T., Kato, C., Hatada, Y., Maruyama, T., Abe, F. and Konishi, M. (2012) New type of pressurized cultivation method providing oxygen for piezotolerant yeast. JBiosci. Bioeng. 113, 220-223.



Klippel, B., Lochner, A., Bruce, D.C., Davenport, K.W., Detter, C., Goodwin, L.A., Han, J., Han, S., Land, M.L., Mikhailova, N., Nolan, M., Pennacchio, L., Pitluck, S., Tapia, R., Woyke, T., Wiebusch, S., Basner, A., Abe, F., Horikoshi, K., Keller, M., Antranikian, G. (2011) Complete genome sequence of the marine, cellulose and xylan degrading bacterium Glaciecola sp. 4H-3-7+YE-5. J. Bacteriol. 193, 4547-4548.

Klippel, B., Lochner, A., Bruce, D. C., Davenport, K. W., Detter, C., Goodwin, L. A., Han, J., Han, S., Land, M. L., Nolan, M., Ovchinnikova, G., Pennacchio, L., Pitluck, S., Tapia, R., Woyke, T., Wiebusch, S., Basner, A., Abe, F., Horikoshi, K., Keller, M., Antranikian, G. (2011) Complete Genome Sequences of Krokinobacter sp. 4H-3-7-5 and Lacinutrix sp. 5H-3-7-4, polysaccharide-degrading members of the family Flavobacteriaceae. J. Bacteriol. 193, 4545-4546.

Nishiguchi, Y., Abe, F. and Okada, M. (2011) Different pressure resistance of lactate dehydrogenases from hagfish is dependent on habitat depth and caused by tetrameric structure dissociation. Marine Biotech. 13, 137-141.



Hiraki, T. and Abe, F. (2010) Overexpression of SNA3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1. FEBS Lett. 584, 55-60.

Hiraki, T., Usui, K. and Abe, F. (2010) Overexpression of EAR1 and SSH4 that encode PPxY proteins in the multivesicular body provides stability of tryptophan permease Tat2 allowing yeast cells to grow under high hydrostatic pressure. High Pressure Research 30, 514-518.



Abe, F., Usui, K. and Hiraki, T. (2009) Fluconazole modulates membrane rigidity, heterogeneity and water penetration into the plasma membrane in Saccharomyces cerevisiae. Biochemistry 48, 8494-8504.

Abe, F. and Hiraki, T. (2009) Mechanistic role of ergosterol in membrane rigidity and cycloheximide resistance in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788, 743-752.

Muthusamy, B-P, Raychaudhuri, S., Natarajan, P., Abe, F., Liu, K., Prinz, W. A. and Graham, T. R. (2009) Control of Protein and Sterol Trafficking by Antagonistic Activities of a P4-ATPase and Oxysterol Binding Protein Homologue. Mol. Biol. Cell 20, 2920-2931.

Guan, X., Souza, C., Pichler, H., Dewhurst, G., Schaad, O., Kajiwara, K., Wakabayashi, H., Ivanova, T., Castillon, G., Piccolis, M., Abe, F., Loewith, R., Funato, K., Wenk, M., and Riezman, H. (2009) Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol. Biol. Cell 20, 2083-2095.

Abe, F., Van Prooyen, N., Ladasky, J. J. and Edidin, M. (2009) Interaction of Bap31 and class I MHC molecules and their traffic out of the endoplasmic reticulum. J. Immunol. 182, 4776-4783.

Daicho, K., Makino, N. Hiraki, T., Ueno, M., Uritani, M., Abe, F. and Ushimaru, T. (2009) Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant. FEMS Microbiol. Lett. 298, 218-227.

Kawano, H., Takahashi, H., Abe, F., Kato, C., and Horikoshi, K. (2009) Identification and characterization of two alternative σ factors of RNA polymerase in the deep-sea piezophilic bacterium, Shewanella violacea strain DSS12. Biochem. Biosci. Biotechnol. 73, 200-202.

Dohi, T., Borodovsky, A., Wu, P., Shearstone, JR., Kawashima, R., Runkel, L., Rajman, L., Dong, X., Scott, ML., Michaelson, JS., Jakubowski, A., Burkly, LC. (2009). TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis. Gastroenterology 136, 912-923.

Koda, T., Kijimoto-Ochiai, S., Uemura, S., and Inokuchi, J. (2009) Specific expression of Neu2 type B in mouse thymus and the existence of a membrane-bound form in COS cells. Biochem. Biophys. Res. Commun. 387, 729-735.

Chisada, S., Yoshimura, Y., Sakaguchi, K., Uemura, S., Go, S., Ikeda, K., Uchima, H., Matsunaga, N., Ogura, K., Tai, T., Okino, N., Taguchi, R., Inokuchi, J., and Ito, M. (2009) Zebrafish and mouse alpha2,3-sialyltransferases responsible for synthesizing GM4 ganglioside. J. Biol. Chem. 284, 30534-30546.

Uemura, S., Yoshida, S., Shishido, F., and Inokuchi, J. (2009) The cytoplasmic tail of GM3 synthase defines its subcellular localization, stability, and in vivo activity. Mol. Biol. Cell 20, 3088-3100.



Abe, F. and Minegishi, H. (2008) Global screening of genes essential for growth in high-pressure and cold environments: searching for basic adaptive strategies using a yeast deletion library. Genetics 178, 851-872.

Ohmae, E., Tatsuta, M., Abe, F., Kato, C., Tanaka, N., and Kunugi, S., and Gekko, K. (2008) Effects of pressure on enzyme function of Escherichia coli dihydrofolate reductase. Biochim. Biophys. Acta 1784, 1115-1121.

Nishiguchi, Y., Miwa, T. and Abe, F. (2008) Pressure-adaptive differences in lactate dehydrogenases of three hagfishes: Eptatretus burgeri, Paramyxine atami, and Eptatretus okinoseanus. Extremophiles 12, 477-480.

Kawamura, YI., Toyota, M., Kawashima, R., Hagiwara, T., Suzuki, H., Imai, K., Shinomura, Y., Tokino, T., Kannagi, R., Dohi, T. (2008). DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. Gastroenterology 135, 142-151.



Abe, F. (2007) Induction of DAN/TIR yeast cell wall mannoprotein genes in response to high hydrostatic pressure and low temperature. FEBS Lett. 581, 4993-4998.

Kanamasa, S., Sumi, K., Yamuki, N., Kumasaka, T., Miura, T., Abe, F., Kajiwara, S. (2007) Cloning and functional characterization of the copper/zinc superoxide dismutase gene from the heavy-metal-tolerant yeast Cryptococcus liquefaciens strain N6. Mol. Genet. Genomics 277, 403-412.

Kawashima, R., Kojima, H., Nakamura, K., Arahata, A., Fujita, Y., Tokuyama, Y., Saito, T., Furudate, S., Kurihara, T., Yagishita, S., Kitamura, K., Tamai, Y. (2007). Alterations in mRNA expression of myelin proteins in the sciatic nerves and brains of streptozotocin-induced diabetic rats. Neurochem. Res. 32, 1002-1010.

Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, YI., Toyama-Sorimachi, N., Imai, T., Dohi, T. (2007). Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. J Immunol. 179, 7478-7487.

Uemura, S., Feng, F., Kume, M., Yamada, K., Kabayama, K., Nishimura, S., Igarashi, Y., and Inokuchi, J. (2007) Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers. Glycobiology 17, 568-577.

Uemura, S., Kihara, A., Iwaki., S, Inokuchi, J., and Igarashi, Y. (2007) Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2. J. Biol. Chem. 282, 8613-8621.



Ladasky, J.J., Boyle, S., Seth, M., Li, H., Pentcheva, T., Abe, F., Steinberg, S.J. and Edidin, M. (2006) Bap31 enhances the ER export and quality control of human class I MHC molecules. J. Immunol. 177, 6172-6281.

Minegishi, H., Miura, T., Yoshida, Y., Usami, R. and Abe, F. (2006) Phylogenetic analysis of pectin-degrading yeasts from deep-sea environments. J. Jpn. Soc. Extremophiles 5, 21-26.

Miura, T., Minegishi, H., Usami, R. and Abe, F. (2006) Systematic analysis of HSP genes on expression, cell growth and survival at high hydrostatic pressure in Saccharomyces cerevisiae. Extremophiles 10, 279-284.

Abe, F., Minegishi, H., Miura, T., Nagahama, T., Yoshida, Y., Usami, R. and Horikoshi, K. (2006) Characterization of cold- and high-pressure-active polygalacturonases from a deep-sea yeast Cryptococcus liquefaciens strain N6. Biochem. Biosci. Biotechnol. 70, 296-299.

Kuwada, M., Kawashima, R., Nakamura, K., Kojima, H., Hasumi, H., Maki, J. (2006). Study of neonatal exposure to androgenic endocrine disruptors, testosterone and dihydrotestosterone by normal-phase HPLC. Biomed Chromatogr. 20, 1237-1241.

Kawashima, R., Kawamura, YI., Kato, R., Mizutani, N., Toyama-Sorimachi, N., Dohi, T. (2006). IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Gastroenterology 131, 130-141.

Noguchi, M., Kabayama, K., Uemura, S., Kang BW, Saito, M., Igarashi, Y., and Inokuchi, J. (2006) Endogenously Produced Ganglioside GM3 Endows Etoposide and Doxorubicin Resistance by Up-regulating Bcl-2 Expression in 3LL Lewis Lung Carcinoma Cells. Glycobiology 16, 641-650.

Uemura, S., Kurose, T., Suzuki, T., Yoshida, S., Ito, M., Saito, M., Igarashi, Y., and Inokuchi, J. (2006) Substitution of the N-glycan Function in Glycosyltransferases by Specific Amino Acids (SUNGA): ST3Gal-V as a model enzyme. Glycobiology 16, 258-270.



Abe, F. and Horikoshi, K. (2005) Enhanced production of isoamyl alcohol and isoamyl acetate by ubiquitination-deficient Saccharomyces cerevisiae mutants. Cell. Mol. Biol. Lett. 10, 383-388.

Kawano, H., Nakasone, K., Abe, F., Kato, C., Yoshida, Y., Usami, R. and Horikoshi, K. (2005). Protein-DNA interactions under high-pressure conditions, studies with Capillary Narrow-tube Electrophoresis. Biochem. Biosci. Biotechnol. 69, 1415-1417.

Kawano, H., Abe, F., Nakasone, K., Kato, C., Yoshida, Y., Usami, R. and Horikoshi, K. (2005). Cloning and characterization of the rpoE gene encoding an RNA polymerase -E factor from the deep-sea piezophilic Shewanella violacea strain DSS12. DNA Sequence 16, 69-74.

Kawano, H., Nakasone, K., Abe, F., Kato, C., Yoshida, Y., Usami, R. and Horikoshi, K. (2005) Identification of rpoBC genes encoding for B and B' subunits of RNA polymerase in a deep-sea piezophilic bacterium, Shewanella violacea strain DSS12. Biochem. Biosci. Biotechnol. 69, 575-582.

Kawamura, YI., Kawashima, R., Fukunaga, R., Hirai, K., Toyama-Sorimachi, N., Tokuhara, M., Shimizu, T., Dohi, T. (2005). Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. Cancer Res. 65, 6220-6227.

Dohi, T., Ejima, C., Kato, R., Kawamura, YI., Kawashima, R., Mizutani, N., Tabuchi, Y., Kojima, I. (2005). Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology. 128, 411-423.

Sato, T., Zakaria, A.M., Uemura, S., Ishii, A., Ohno-Iwashita,Y., Igarashi, Y., and Inokuchi, J. (2005) Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Glycobiology 15, 687-699.

Kabayama, K., Sato, T., Kitamura, F., Uemura, S., Kang, BW., Igarashi, Y., and Inokuchi, J.. (2005) TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. Glycobiology 15, 21-29.



Miura, T. and Abe, F. (2004) Multiple ubiquitin-specific protease genes are involved in degradation of yeast tryptophan permease Tat2 at high pressure. FEMS Microbiol. Lett. 239, 171-179.

Kawano, H., Nakasone, K., Matsumoto, M., Usami, R., Kato, C. and Abe, F. (2004) Differential pressure resistance in the activity of RNA polymerase isolated from Shewanella violacea and Escherichia coli. Extremophiles 8, 367-375.

Nagayama, A., Kato, C. and Abe, F. (2004) The N- and C-terminal mutations in tryptophan permease Tat2 confer cell growth in Saccharomyces cerevisiae under high-pressure and low-temperature conditions. Extremophiles 8, 143-149.

Kawano, H., Suzaki, Y., Fukuchi, J., Nakasone, K., Abe, F., Kato, C., Yoshida, Y., Usami, R. and Horikoshi, K. (2004) Cloning and overproduction of the rpoZ Gene Encoding an RNA polymerase omega- subunit from a deep-sea piezophilic Shewanella violacea strain DSS12. DNA Sequence 15, 118-122.

Kuwada, M., Kawashima, R., Furudate, S., Sugano, S., Maki, J. (2004). One-step analysis of testis steroidogenesis from neonatal exposure to synthetic estrogen by normal-phase HPLC. Biomed. Chromatogr. 18, 234-239.

Inokuchi, J., Kabayama, K., Uemura, S., and Igarashi, Y. (2004) Glycospingolipids govern gene expression. Glycoconj. J. 20, 169-178.



Abe, F. and Iida, H. (2003) Pressure-induced differential regulation of the two tryptophan permeases Tat1 and Tat2 by ubiquitin ligase Rsp5 and its binding proteins, Bul1 and Bul2. Mol. Cell. Biol. 23, 7566-7584. (+ Cover illustration)

Kawamura, YI., Kawashima, R., Shirai, Y., Kato, R., Hamabata, T., Yamamoto, M., Furukawa, K., Fujihashi, K., McGhee, JR., Hayashi, H., Dohi, T. (2003). Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation. Eur J Immunol. 33, 3205-3212.

Uemura, S., Kihara, A., Inokuchi, J., and Igarashi, Y. (2003) Csg1p and Newly Identified Csh1p Function in Mannosylinositol Phosphorylceramide Synthesis by Interacting with Csg2p. J. Biol. Chem. 278, 45049-45055.

Uemura, S., Kabayama, K., Noguchi, M., Igarashi, Y., and Inokuchi, J. (2003) Sialylation and Sulfation of Lactosylceramide Distinctly Regulate Anchorage-Independent Growth, Apoptosis and Gene Expression in 3LL Lewis Lung Carcinoma Cells. Glycobiology 13, 207-216.



Miura, T., Abe, F., Inoue, A., Usami, R. and Horikoshi, K. (2002) Superoxide dismutase is involved in high tolerance to copper in the deep-sea yeast Cryptococcus sp. N6. Biotechnol. Lett. 24, 1069-1074.

Kuwada, M., Kawashima, R., Nakamura, K., Kojima, H., Hasumi, H., Maki, J., Sugano, S. (2002) Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty. Biochem. Biophys. Res. Commun. 295, 193-197.

Tagami, S., Inokuchi, J., Kabayama, K., Yoshimura, H., Kitamura, F., Uemura, S., Ogawa, C., Ishii, A., Saito, M., Ohtsuka, Y., Sakaue, S., and Igarashi, Y. (2002) Ganglioside GM3 Participates in the Pathological Conditions of Insulin Resistance. J. Biol. Chem. 277, 3085-3092.



Abe, F., Miura, T., Nagahama, T., Inoue, A., Usami, R. and Horikoshi, K. (2001) Isolation of a highly copper-tolerant yeast, Cryptococcus sp., from the Japan Trench and the induction of superoxide dismutase activity by Cu2+. Biotechnol. Lett. 23, 2027-2034.

Miura, T., Abe, F., Inoue, A., Usami, R. and Horikoshi, K. (2001) Purification and characterization of novel extracellular endopolygalacturonases from a deep-sea yeast, Cryptococcus sp. N6, isolated from the Japan Trench. Biotechnol. Lett. 23, 1735-1739.



Abe, F. and Horikoshi, K. (2000) Tryptophan permease gene TAT2 confers high-pressure growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 8093-8102.

Inokuchi, J., Uemura, S., Kabayama, K., and Igarashi, Y. (2000) Glycosphingolipid Deficiency Affects Functional Microdomain Formation in Lewis Lung Carcinoma. Glycoconj.J. 17, 239-246.

Abe, F. (1998) Hydrostatic pressure enhances vital staining with carboxyfluorescein or carboxydichlorofluorescein in Saccharomyces cerevisiae: Efficient detection of labeled yeasts by flow cytometry. Appl. Environ. Microbiol. 64, 1139-1142.

Abe, F. and Horikoshi, K. (1997) Vacuolar acidification in Saccharomyces cerevisiae induced by elevated hydrostatic pressure is transient and is mediated by vacuolar H+-ATPase. Extremophiles 1, 89-93.

Okafuji, T., Abe, F. and Maeda, Y. (1997) Antisense-mediated regulation of Annexin VII gene expression during the transition from growth to differentiation in Dictyostelium discoideum. Gene 189, 49-56.

Abe, F. and Horikoshi, K. (1995) Hydrostatic pressure promotes the acidification of vacuoles in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 130, 307-312.

Abe, F. and Maeda, Y. (1995). Specific expression of a gene encoding a novel calcium-binding protein, CAF-1, during transition of Dictyostelium cells from growth to differentiation (1995). Dev. Growth Differ. 37, 39-48.

Abe, F. and Maeda, Y. (1994) Precise expression of the cAMP receptor gene, CAR1, during transition from growth to differentiation in Dictyostelium discoideum. FEBS Lett. 342, 239-241.

Maeda, Y., Ohmori, T., Abe, T., Abe, F. and Amagai, A. (1989). Transition of starving Dictyostelium cells to differentiation phase at a particular position of the cell cycle. Differentiation 41, 169-175.



Abe, F. (2021) Molecular responses to high hydrostatic pressure in eukaryotes: Genetic insights from studies on Saccharomyces cerevisiae. Biology (Basel).10:1305.

Abe, F. (2015) Effects of high hydrostatic pressure on microbial cell membranes: Structural and functional perspectives, In: High Pressure Bioscience -Basic Concepts, Applications and Frontiers, Springer, Subcellular Biochemistry (SBM), 72, 371-381.

Abe, F. (2015) Stress responses of the yeast Saccharomyces cerevisiae under high hydrostatic pressure, In: Stress Biology of Yeasts and Fungi: Application for Industrial Brewing and Fermentation, Springer, 77-92.

Abe, F. (2013) Dynamic structural changes in microbial membranes in response to high hydrostatic pressure analyzed using time-resolved fluorescence anisotropy measurement. Biophys. Chem. 183, 3-8.

Abe, F. (2010) High pressure and eukaryotes, In Extremophiles Handbook (eds. K. Horikoshi, G. Antranikian, A. T. Bull, F. T. Robb, K. O. Stetter), 687-702, Springer, Heidelberg, Germany

Abe, F. (2010) Isolation method for high-pressure growth mutants, In Extremophiles Handbook (eds. K. Horikoshi, G. Antranikian, A. T. Bull, F. T. Robb, K. O. Stetter),727-735, Springer, Heidelberg, Germany.

Abe, F. (2008) Use of mutant strains of yeast in the brewing industry. In Encyclopedic Handbook of Beer in Health and Disease Prevention (eds. V. R. Preedy and R. Watson), 11-21, Elsevier.

Abe, F. (2008) Effects of growth-permissive pressure on the growth and the physiology of Saccharomyces cerevisiae. In High-Pressure Microbiology (eds. C. Michiels and D. H. Bartlett), 167-179, ASM Press, Washington DC

Kato, C., Sato, T., Abe, F., Ohmae, E., Tamegai, H., Nakasone, K., Siddiqui, K.S. and Thomas, T. (2007) Protein adaptation to high-pressure environments. In: Protein Adaptation in Extremophiles. Molecular Anatomy and Physiology of proteins series (eds. Thomas, T. and Siddiqui, K.S.), Nova Science Publisher, 167-191.

Abe, F. (2007) Exploration of the effects of high hydrostatic pressure on microbial growth, physiology and survival: perspectives from piezophysiology. Biochem. Biosci. Biotechnol.,71, 2347-2357.

Abe, F. (2007) Regulation and dynamics of yeast tryptophan permeases studied using hydrostatic pressure. International Congress Series 1304C, 75-84.

Abe, F. (2004) Piezophysiology of yeast -Occurrence and significance. Cell. Mol. Biol. 50, 437-445.

Abe, F., Kato, C. and Horikoshi, K. (2004) Extremophiles: Pressure. In Microbial Diversity and Bioprospecting (ed. A. T. Bull), 154-159, ASM Press, Washington DC.

Abe, F. and Horikoshi, K. (2001) The biotechnological potential of piezophiles. Trends Biotechnol. 19, 102-108. (+ Cover illustration)

Abe, F., Kato, C. and Horikoshi, K. (1999) Pressure-regulated metabolism in microorganisms. Trends Microbiol. 7, 447-453.

Abe, F. and Horikoshi, K. (1998) Analysis of intracellular pH in the yeast Saccharomyces cerevisiae under elevated hydrostatic pressure: a study in baro-(piezo-) physiology. Extremophiles 2, 223-228.


Conference Proceedings

Abe, F. (2007) Probing for dynamics of amino acid uptake in living yeast using hydrostatic pressure. Proceedings for the 4th International Conference on High Pressure Bioscience and Biotechnology (eds. Abe, F., and Suzuki, A.), 1, 134-138.

Kato, C., Sato, T., Abe, F., Ohmae, E., Tamegai, H. and Nakasone, K. (2007) Discovery of deep-sea piezophiles, and their adapted enzymes. Proceedings for the 4th International Conference on High Pressure Bioscience and Biotechnology (eds. Abe, F., and Suzuki, A.), 1, 114-121.

Abe, F. (2007) Physiological effects of increasing hydrostatic pressure in yeast. Proceedings for International Symposium on Extremophiles and Their Applications (ISEA2005), 262-265.

Kawano, H., Nakasone K., Abe, F., Matsumoto M., Kato, C., Usami, R., and Horikoshi, K. (2004) Effects of high hydrostatic pressure on the transcriptional activity of RNA polymerase of the deep-sea piezophilic bacterium Shewanella violacea DSS12. Proceedings for the 6th International Conference (IMBC) on Marine Biotechnology, in press.

Abe. F. (2003) The role of tryptophan permease Tat2 in cell growth of yeast under high-pressure condition. In Advances in High Pressure Bioscience and Biotechnology II (ed. Winter, R.) 271-274, Springer.

Abe, F. and Horikoshi, K. (2002) The biological significance of tryptophan availability on high-pressure growth in yeast. In Trends in High Pressure Bioscience Biotechnology (eds. Hayashi, R., Balny, C.) 219-226, Elsevier.

Sohirad, M., Miwa, T., Abe, F. and Aizawa, M. (2002) Cytoskeletal adaptation of living mammalian cells surviving under extremely high hydrostatic pressure. In Trends in High Pressure Bioscience and Biotechnology (eds. Hayashi, R., Balny, C.) 259-263, Elsevier.

Abe, F. and Horikoshi, K. (2000) Metabolic changes in glycolysis in yeast induced by elevated hydrostatic pressure. - A study in baro-(piezo-)physiology. In Science and Technology of High-Pressure Research, University Press, Hyderabad, India, 335-337.

Abe, F. and Horikoshi, K. (1999) A new application of moderate hydrostatic pressure for efficient detection of living yeast by flow cytometry. In Advances in High Pressure Bioscience and Biotechnology (ed. Ludwig, H.) 507-510, Springer.

Abe, F. and Kato, C. (1999) Barophysiology (Piezophysiology). In Extremophiles in Deep-Sea Environments (eds. Horikoshi, K., Tsujii, K.) 227-248, Springer.

Abe, F. and Horikoshi, K. (1998) Vacuolar acidification in Saccharomyces cells in response to elevated hydrostatic pressure. In Rev High Pressure Science and Technology (ed. Nakahara, M.) 7, 1312-1314.

Abe, F. (1998) A possible function of the yeast vacuole in cytoplasmic pH homeostasis under hydrostatic pressure. In High Pressure Biology and Medicine (eds. Bennet, P. B., Demchenko, I., Marquis, R. E.) 38-43, University of Rochester Press, New York.

Abe, F. and Horikoshi, K. (1997) Yeast vacuoles may serve as proton sequestrants under high hydrostatic pressure. In High Pressure Research in the Bioscience and Biotechnology (ed. Heremans, K.) 209-212, Leuven University Press, Leuven, Belgium.

Abe, F. and Horikoshi, K. (1996) Vacuolar acidification under high hydrostatic pressure in Saccharomyces cerevisiae. In High Pressure Bioscience and Biotechnology (ed. Hayashi R, Balny C) 13, 53-58, Elsevier, Amsterdam.

Abe, F. and Horikoshi, K. (1995) Effect of hydrostatic pressure on the yeast vacuole. In High Pressure Science and Technology (ed. Trzeciakowski W. A.) 875-877, World Scientific Publishing, Singapore.



阿部文快、酵母のメカノセンシングと高水圧ストレス応答、エヌ・ティー・エス出版, 2023

阿部文快、出芽酵母の圧力生理学、高圧力の科学・技術事典 414–415, 2022


阿部文快、複雑系としての細胞内分子間ネットワークに 及ぼす高水圧の効果、高圧力の科学と技術 31, 54–65, 2021




阿部文快 (2013) 出芽酵母における非致死的圧力への応答と適応 〜ゲノムからのアプローチ、“進化する食品高圧加工技術”、エヌ・ティー・エス出版、85-95.


阿部文快 (2013) 高圧力下における微生物細胞膜の動的構造、高圧力の科学と技術 23, 47-52.


阿部文快 (2012) 好圧性細菌における膜物性の直接計測 ー高圧蛍光偏光解消法からのアプローチー J. Jpn. Soc. Extremophiles 11, 83-89.

阿部文快 (2009) 圧力にまつわる極限環境生物研究の10年後、J. Jpn. Soc. Extremophiles 8, 31-32.

福岡伸一、川島麗(1章訳者)マッキー生化学 第4版 市川厚 監修、福岡伸一 監訳(化学同人)

阿部文快 (2008) 出芽酵母における高圧・低温応答遺伝子の網羅的発現解析、高圧バイオサイエンスとバイオテクノロジー (J-STAGE) 2, 109-114.

西口慶一、阿部文快、加藤千明、三輪哲也、佐藤孝子、大島範子、岡田光正 (2008) 円口類乳酸脱水素酵素の構造と機能、高圧バイオサイエンスとバイオテクノロジー (J-STAGE) 2, 54-60.

加藤千明、佐藤孝子、阿部文快、大前英司、為我井秀行、仲宗根薫 (2008) 高圧下への蛋白質の適応、高圧バイオサイエンスとバイオテクノロジー (J-STAGE) 2, 45-53.

阿部文快 (2008) 微生物生理におよぼす圧力効果、高圧力の科学と技術18, 119-127.

阿部文快 (2007) 圧力をツールとした出芽酵母のストレス応答解析、バイオサイエンスとインダストリー 65, 557-559.

阿部文快 (2006) 圧力をツールとした酵母のトリプトファン輸送の動態解析、さんえい出版(京都)、211-220.

三浦健、阿部文快 (2006) 出芽酵母における高圧増殖には脱ユビキチン化酵素が関わっている、さんえい出版(京都)、221-228.

峯岸宏明、宇佐美論、阿部文快 (2006) 出芽酵母のエルゴステロール生合成の遺伝子破壊株が示す高圧/低温感受性について、さんえい出版(京都)、229-236.

峯岸宏明、阿部文快、宇佐美論、掘越弘毅 (2006) 出芽酵母遺伝子破壊ライブラリーを用いた高圧/低温感受性株の網羅的探索、さんえい出版(京都)、255-262.

三浦健、阿部文快 (2006) 出芽酵母におけるストレス関連遺伝子の発現と高圧増殖/耐圧性への関与について、さんえい出版(京都)、269-274.

阿部文快、峯岸宏明、三浦健 (2006) 酵母遺伝子破壊ライブラリーを用いた高圧増殖に必須な遺伝子の同定、さんえい出版(京都)、275-282.

阿部文快 (2004) 圧力が探る酵母の生理機能と膜タンパク質の動態、化学と生物 42, 435-445. (+ 表紙ページ写真

阿部文快 (2004) 出芽酵母の圧力生理学、月刊海洋36, 604-610

阿部文快、松本雅光 (2004) 高圧分光蛍光測定システムの開発と酵母細胞内pHの測定、月刊海洋36, 685-689.

阿部文快 (2004) “圧力生理学”から見えてきた細胞機能と動態、日本農芸化学会誌 78, 396-398.

阿部文快、永山あい、加藤千明、掘越弘毅 (2003) 酵母の高圧増殖におけるトリプトファン輸送の重要性 −圧力生理学 (Piezophysiology) の観点から− 山本克博編、さんえい出版(京都)、45-51.

阿部文快 (2002) 蛍光顕微鏡を用いた酵母菌の観察、微生物利用の大展開、エヌ・ティー・エス出版、383-386.

井ノ口仁一,樺山一哉,上村聡志,五十嵐靖之 (2002) ラクトシルセラミド分岐とドメイン形成、蛋白質 核酸 酵素 47, 371-378

阿部文快 (2001) 出芽酵母における圧力とラパマイシンの類似効果、バイオサイエンスとインダストリー 59, 36-37.

阿部文快 (2001) 圧力研究から見えてきた酵母の生理学、生物工学会誌 79, 449.

阿部文快 (1999) 高圧下における蛍光測定と出芽酵母における圧力効果、材料技術、17, 153-160.

阿部文快、掘越弘毅(1998)高圧負荷による酵母細胞内pHの変動とその生理的意義 −圧力生理学Baro- (Piezo-) physiologyの観点から− 高圧バイオテクノロジー、功刀滋・林力丸編、111-119、さんえい出版(京都)

阿部文快、水越正、三浦健、宇佐美論、井上明、掘越弘毅(1998)日本海溝から単離された深海酵母Cryptococcus sp. N6株の銅耐性に関する研究JAMSTEC J. Deep Sea Res. 14, 573-580.



Yusuke Kato 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)

 "A novel membrane protein Ehg1 physically interacts with with nutrient permeases in the ER allowing yeast cells to grow under high pressure" Best Poster Award (2018.9.18-22)

上村聡志  日本薬学会東北支部奨励賞(2011年12月3日予定、仙台)

上村聡志  日本生化学会東北支部優秀論文賞(2010年5月8日)
      "The cytoplasmic tail of GM3 synthase difines it subcellular localization, stability, and in vivo activity"

Rei Kawashima  Digestive Disease Week Annual Meeting POSTER of DISTINCTION (2008.5.20, San  Diego)

“Interleukin-13 induces tissue damage with relocation of beta-catenin and modification of cell-cell adhesion in the epithelial cells.”

阿部文快  2007堀場雅夫賞(2007年10月17日、京都)


川島 麗  第23回 日本疾患モデル動物学会総会 演題優秀賞(2006年11月30日、伊香保)


上村聡志  日本薬学会東北支部若手研究者発表賞(2006年12月8日)

阿部文快  日本農芸化学会奨励賞(2006年3月25日、京都)


阿部文快  極限環境微生物学会奨励賞(2003年12月1日、和光)


Satoshi Uemura  2nd International "Charleston Ceramide Conference" Poster Award (2003.6.4-7, Italy)
"Identification of two IPC mannosyltransfereses complexes, Csg1p/Csg2p and Ipm1p/Csg2p, in yeast Saccharomyces cerevisiae"